Efficient one-pot synthesis of indol-3-yl-glycines via uncatalyzed Friedel-Crafts reaction in water.
نویسندگان
چکیده
The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
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ورودعنوان ژورنال:
- Molecules
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2009